1. Cut focaccia horizontally in half. Spread cut sides of both halves with pizza sauce. Layer bottom half with pepperoni, cheese and mushrooms; sprinkle with red pepper flakes, if desired. Cover with top of focaccia. Brush outside of sandwich lightly with olive oil.
2. Heat large nonstick skillet over medium heat. Add sandwich; press down lightly with spatula or weigh down with small plate. Cook sandwich 4 to 5 minutes per side or until cheese melts and sandwich is golden brown. Cut into wedges to serve.
Note
Focaccia can be found in the bakery section of most supermarkets. It is often available in different flavors, such as tomato, herb, cheese or onion.